Vigamox ophthalmic drops 0.5% 5ml

Vigamox ophthalmic drops 0.5% 5ml View full size

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Vigamox eye drops is an antibacterial medication with a broad spectrum of bactericidal activity. It contains the active ingredient antibiotic - moxifloxacin (fluoroquinolones). Vigamox is used for the treatment of inflammatory diseases of the eye including conjunctivitis and keratitis caused by microorganisms susceptive to moxifloxacin.

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Vigamox ophthalmic drops 0.5% 5ml

Vigamox ophthalmic drops 0.5% 5ml Vigamox eye drops contain Moxifloxacin as an active ingredient. It used used to treat bacterial infections of the eyes.
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Active ingredient: Moxifloxacin HCI ophthalmic solution 0.5% 5ml

Pharmacological action

Vigamox eye drops contain Moxifloxacin as an active ingredient. It is a V generation fluoroquinolone antibiotic with bactericidal activity.

It is active against a broad spectrum of gram-positive and gram-negative microorganisms, anaerobic, acid-resistant and atypical bacteria.

The mechanism of action is associated with inhibition of topoisomerase II (DNA gyrase) and topoisomerase IV.

DNA gyrase is an enzyme involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme involved in the cleavage of the chromosomal DNA during bacterial cell division.

Moxifloxacin eye drops does not have cross-resistance to macrolides, aminoglycosides and tetracyclines.
Moxifloxacin is active against most strains of microorganisms (such as in vitro, and in vivo)

Vigamox Indications

Vigamox ophthalmic is used to treat bacterial conjunctivitis caused by sensitive to the medication microorganisms.

Vigamox Mode of administration

Vigamox ophthalmic is applied locally. The recommended dosage for adults in 1 drop in the affected eye 3 times daily. The improvement is usually observed in 5 days and the treatment should be continued for 2-3 days. If you do not see any improvement within 5 days, let your doctor know.

The duration of treatment depends on the severity of the disease.


Vigamox ophthalmic drops are contraindicated for use in:

  • Hypersensitivity to any of the medicines ingredients
  • Pregnancy
  • Breastfeeding
  • Children under 1 year of age

There is no sufficient data about the safety use of the medication during pregnancy and lactation. Moxifloxacin belongs to a pregnancy category C meaning that it is not safe to use the medication during pregnancy.

Vigamox can pass through breast milk and therefore, breast-feeding during treatment remedy should be discontinued.

Teratogenicity. Pre-clinical animal studies, moxifloxacin had no teratogenic effects at doses of 500 mg/ kg/day (which is, approximately, 21.700 times the recommended daily human dose). However, there was a decrease in body weight of the fetus, and delayed development of the musculoskeletal system.

Vigamox local ophtalmic side effects

Vigamox is generally well-tolerated and side effects are not common.

In 1-10% of cases there may bet pain, irritation and itching of the eye, a "dry"eye syndrome, conjunctival hyperemia, eye redness.

In 0.1-1% of cases there may be a defect of the corneal epithelium, punctate keratitis, subconjunctival hemorrhage, conjunctivitis, eye swelling, discomfort in the eyes, blurred vision, decreased visual acuity, erythema century, unusual sensations in the eye.

Vigamox systemic side effects
In 1-10% of cases - dysgeusia.

In 0.1-1% of cases - headache, paresthesia, decreased hemoglobin, discomfort in the nose, foreign body sensation in the throat, vomiting, increased alanine aminotransferase and gamma glutamyl.
Post-marketing experience (frequency not known):

Local: endophthalmitis, ulcerative keratitis, corneal erosion, the formation of defects in the cornea, increased intraocular pressure, corneal opacity, corneal infiltrates, corneal deposits, allergic reactions, eye, keratitis, corneal edema, photophobia, blepharitis, eyelid edema , increased lacrimation, eye discharge, foreign body sensation in the eye.

Systemic: palpitations, dizziness, shortness of breath, nausea, erythema, rash, itching of the skin, hypersensitivity reactions.

Vigamox interactions

Medicines interactations between moxifloxacin and other eye medication have not been studied.

Data are available for the oral dosage form of moxifloxacin: there is no clinically significant drug-drug interactions with theophylline, warfarin, digoxin, oral contraceptives, probenecid, ranitidine, and glibenclamide. In in vitro studies, moxifloxacin does not inhibit isozymes CYP3A4, CYP2D6, CYP2C9 or CYP1A2, which may indicate that moxifloxacin does not alter the pharmacokinetics of medicaments metabolized by cytochrome P450.

Special instructions. In patients treated with systemic medications of quinolone group, severe, occasionally fatal hypersensitivity reactions (anaphylaxis), sometimes after the first dose are possible Some reactions were accompanied by a collapse, loss of consciousness, angioedema (including laryngeal edema), airway obstruction, dyspnea, urticaria and pruritus.

Prolonged use of antibiotics can lead to excessive growth of microorganisms, including fungi. In the case of superinfection to stop medication and assign adequate therapy. After remedy may temporarily reduce clarity of vision, and to restore it, it is not recommended to drive and engage in activities that require attention and response.

Do not touch the tip of the bottle dropper to any surface to avoid contamination of the vial and its contents. The bottle should be closed after each use.

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