Cialis generic 20mg (Tadalafil)

Generic Cialis (Tadacip, Tadaga, Tadagra, Tadalis, Vidalista)

Generic Cialis contains the active ingredient – Tadalafil which belongs to a group of medical preparations called PDE5 (phosphodiesterase type 5) inhibitors. PDE5 is the enzyme that breaks down cyclic guanosine monophosphate (cGMP).

When a sexual excitement causes local release of NO, the suppression of PDE5 causes increase of cGMP and the consequent relaxation of smooth muscles. This finally leads to increase of blood inflow to the penis allowing men to achieve firm erection and perform sexual intercourse. Tadalafil 20mg does not work in absence of sexual excitement. The main advantage of Tadalafil that it remains active in the blood for 36 hours allowing to achieve erection during this period after administration.

PDE5 is an enzyme found in the smooth muscle of the cavernous body of the penis , smooth muscles of the internal organs, skeletal muscle, platelets, kidney, lung and cerebellum. It is proved that Tadalafil is 10 000 times more selective for PDE5 than for PDE1, PDE2, PDE4 and PDE7, which are located in the heart, brain, blood vessels, liver, leukocytes, skeletal muscle and other organs. Original Tadalafil is 10 000 times more actively blocks PDE5 than PDE3 - an enzyme that is found in the heart tissue and blood vessels. It means that Tadalafil does not significantly affect these tissues and organs.

In general Calis improves erection and the possibility to perform successful sexual intercourse. After oral administration, tadalafil starts acting in 20-30 minutes.

Generic Cialis indications

Cialis (tadalafil) is used to treat erectile dysfunction in men over 18 years of age. The medication is not used by women or men over 18 years of age.

Generic Cialis Mode of administration

The recommended dose of Cialis generic is 10 mg daily. In men with insufficient therapeutic effect the dosage can be increased up to 20mg daily. Maximal daily dose of Vidalista is 20mg daily. Tadalafil 20mg tablets shoud be taken 20-30 minutes before anticipated sexual activity.
Males may attempt to perform sexual intercourse at any time within 36 hours after taking generic Cialis (Tadacip, Tadaga, Tadagra, Tadalis, Vidalista)

Contraindications and cautions

Generic Cials is contraindicated for use in the following conditions:

• Males with hypersensitivity to tadalafil
• Women and men under 18 years of age
• Concomitant use with nitrates like Nitroglycerin
• Hypotension and hypertension
• Heart disease including angina, congestive heart failure, irregular heartbeats
• Multiple myeloma
• Sickle cell anemia
• Renal diseases including renal failure
• Liver problems (hepatic impairment)
• A history of a heart attack, stroke, or life-threatening arrhythmia within the past 6 months
• Eye problems - Retinitis pigmentosa and NAION
• Stomach and duodenal
• Bleeding diseases
• Sickle cell anemia
• Priapism of predisposition to priapism
• Leukemia
• A history of priapism, which is a painful erection lasting longer than six hours
• Anatomical deformations of the penis such as angulation, cavernosal fibrosis, Peyronie's disease

Cialis generic side effects

Cialis generic (Tadacip, Tadaga, Tadagra, Tadalis, Vidalista) side effects are not common and usually occur in men with overdose and hypersensitivity.

The most frequently reported Tadalafil side effects include headache and dyspepsia (11 and 7%, respectively). Adverse events associated with taking tadalafil were usually mild or moderate in severity, transient and decreased with continued use of the medication.

Other common Cialis effects include back pain, myalgia, nasal congestion and hot flashes.
Other - swelling of the eyelids, eye pain, redness of the conjunctiva, and dizziness.

Cialis generic interaction

Tadalafil and its generic forms : Vidalista, Tadalis, Tadagra, Tadaga, Tadacip can interact with the following groups of medicaments:

• Alcohol
• CYP 3A4 inhibitor medications including Amprenavir, Atazanavir, Clarithromycin, Conivaptan, Darunavir, Delavirdine, Erythromycin, Fosamprenavir, Imatinib, Indinavir Isoniazid, Itraconazole, Ketoconazole, Lopinavir and ritonavir, Miconazole, Nefazodone, Nelfinavir Nicardipine, Posaconazole, Quinidine, Ritonavir, Saquinavir, Telithromycin, Voriconazole
• Alpha blockers
• Blood pressure medications
• Nitrates (Nitroglycerin, Isosorbide dinitrate, Isosorbide mononitrate)
• Other PDE5 inhibitor