Caverta 100mg

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100mg - 12 tablets
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Caverta is, used for the treatment of pulmonary arterial hypertension and erectile dysfunction. Scientists Andrew Bell, David Brown, and Nicholas Terrett from Pfizer first discovered the medicine. It works through inhibition of cGMP-specific phosphodiesterase type 5 (PDE5).

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Caverta 100mg

Caverta 100mg Caverta is, used for the treatment of pulmonary arterial hypertension and erectile dysfunction. Scientists Andrew Bell, David Brown, and Nicholas Terrett from Pfizer
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Caverta is, used for the treatment of pulmonary arterial hypertension and erectile dysfunction. Scientists Andrew Bell, David Brown, and Nicholas Terrett from Pfizer first discovered the drug. It works through inhibition of cGMP-specific phosphodiesterase type 5 (PDE5). This is an enzyme that carries forward cGMP degradation, which in turn regulates blood flow in the penis. It has been launched in 1998 and along with tadalafil and vardenafil are the most used drugs for the treatment of erectile dysfunction.

Caverta

Qualitative and quantitative composition: Each film coated tablet of Caverta 100mg contains 25, 50 or 100 mg sildenafil citrate equivalent to the same amount of sildenafil. The coat further contains 0.834, 1.667 and 3.334 mg of lactose (as monohydrate) respectively.

Pharmacological action: Caverta works through inhibition of cGMP-specific phosphodiesterase type 5 (PDE5). This is an enzyme that carries forward cGMP degradation, which in turn regulates blood flow in the penis. But it cannot work without sexual stimulation and cannot be used to increase libido.

Therapeutic indications: Caverta is indicated for the treatment of erectile dysfunction in adult men who cannot maintain sufficient penile erection for satisfactory sexual performance. For Caverta to work sexual stimulation is necessary. It cannot be used in adult women and children and it does not increase the libido.

Contraindications: Caverta 100mg cannot be given to patients having hypersensitivity to it. Further, it has hypotensive effects of nitrates thus cannot be co-administered with nitric oxide donors. It should not be administered in patient with severe cardiac disorder and others who had been advised against sexual activity.

Caverta is also contraindicated in patients suffering from loss of vision in one eye due to non-arteritic anterior ischaemic optic neuropathy (NAION). Effect of Caverta 100mg  is still not fully of stroke, and hereditary retinal disorder.

Special warnings and precautions for use: Administration of Caverta should be done with caution if the patient has cardiovascular risk factors. Severe cardiovascular problems have been noted after use of Caverta (cerebrovascular haemorrhage, myocardial infarction, sudden cardiac death, ventricular arrhythmia, transient ischaemic attack, hypertension and hypotension, unstable angina).

Patients suffering from priapism and anatomical deformation (cavernosal fibrosis, angulation or Peyronie's disease) of the penis proper treatment should be done instead of using Caverta as it may cause permanent loss of sexual potency. Prolonged erections are another aspect that need to be monitored and if erection persists for more than four hours immediate assistance of doctors should be taken.

It has hypotensive effects of nitrates thus cannot be coadministered with nitric oxide donors. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction and, with ritonavir, alpha blockers (can have systematic hypotension) is not advisable. Caverta is also contraindicated in patients suffering from loss of vision in one eye due to non-arteritic anterior ischaemic optic neuropathy (NAION). Caverta can also cause peptic ulcer and bleeding disorder, though no specific case has been reported. The coating contains lactose, so cannot be used for patients suffering from galactose intolerance. Caverta 100mg is not for adult women and children.

Interaction with other medicinal products: Inhibitors of cytochrome P450 (CYP) isoforms 3A4 (major route) and 2C9 (minor route) through which metabolism of Caverta takes place, can cause reduction in the rate of Caverta clearance. Similarly inducers of these isoenzymes will increase clearance of Caverta.

Nicorandil (hybrid of potassium channel activator and nitrate) can cause severe interaction with Caverta because of the nitrate component.

The drugs, including antacids (aluminium or magnesium hydroxide); Dipyridamole/ theophylline (non-specific phosphodiesterase inhibitors); tolbutamide; warfarin; acetyl salicylic acid; HIV protease inhibitors (ritonavir/ saquinavir) have no direct interaction with Caverta and do not hamper the bioavailability of Caverta. Caverta is also not affected by consumption of alcohol as per studies made (up to 80 mg/dl alcohol levels in blood).

Undesirable effects: Patients treated with Caverta have several adverse reactions that may include blurred vision, dizziness, nasal congestion, hot flush, headache, cyanopsia, nausea, and dyspepsia.

Interesting facts:

  •   Caverta is an amazingly successful medicine and the fastest selling drug yet (around $2 billion sales).
  •   Though Caverta is very effective in getting erection in the presence of sexual stimuli, it cannot increase the libido.

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