Augmentin tablets

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250mg/125mg - 10 tablets
250mg/125mg - 30 tablets
500mg/125mg - 10 tablets
500mg/125mg - 30 tablets
875mg/125mg - 10 tablets
875mg/125mg - 30 tablets

Augmentin is a combination of oral antibiotics composed of amoxicillin and clavulanate potassium i.e. the potassium salt of clavulanic acid which acts as the beta-lactamase inhibitor.

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Augmentin tablets

Augmentin tablets Augmentin tablets for different infections as dental, urinary tract infection, respiratory and other
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Augmentin tablets is a combination of oral antibiotics composed of amoxicillin and clavulanate potassium i.e. the potassium salt of clavulanic acid which acts as the beta-lactamase inhibitor.

Augmentin tablets

Qualitative and quantitative composition: Augmentin is available in 375 mg tablets and 156 mg suspensions. Each tablet contains 250 mg amoxicillin (in the form of amoxicillin trihydrate) and 125 mg clavulanic acid (as potassium clavulanate). Similarly, each 5 ml suspension contains 125 mg amoxicillin (as amoxicillin trihydrate) and 31.25 mg clavulanic acid (in the form of potassium clavulanate).

Pharmacological action: Since the semisynthetic antibiotic amoxicillin (a good antibiotic against Gram-positive and Gram-negative bacteria) is vulnerable to β-lactamase degradation it has limited activity against bacteria producing β-lactamase. In this scenario clavulanic acid present in augmentin has the ability to inactivate β-lactamase produced by many bacteria (also against plasmid mediated β-lactamase responsible for transfer of drug resistance). Thus augmentin can be used in cases with reports of amoxicillin resistance.

Therapeutic indications: Augmentin tablets has a wide range of indications for short-term treatment of bacterial infections at different sites including: ENT or upper and lower respiratory tract infections (sinusitis, tonsillitis, bronchopneumonia, chronic bronchitis); Skin and soft tissue infections (abscesses, wound infections); Genito-urinary tract infections (urethritis, cystitis); Dental infections (dentoalveolar abscess) Bone and joint infections (osteomyelitis) etc.

Contraindications: Augmentin tablets can be regarded as contraindicated in patients with history of β-lactam (penicillins and cephalosporins) hypersensitivity and augmentin associated jaundice or hepatic dysfunction.

Special warnings and precautions for use: Patients with hypersensitivity to penicillin and cephalosporin or other allergens should be very carefully considered before administration of augmentin as fatal hypersensitivity can occur. Avoiding augmentin is also advisable for patients with mononucleosis infections because of the threat of morbilliform rash.

As with other penicillin groups of antibiotics, prolonged use may result in overgrowth of organisms not susceptible to augmentin. Increase of prothrombine time is also observed in certain patients receiving both augmentin and anti-coagulants. So such patients should be closely monitored and the dose should be regulated accordingly.

Some changes in liver and renal functions have also been noticed in rare cases, making it necessary to use caution while giving augmentin to patients with hepatic or renal disorders. Adequate fluid intake during administration of high dose of augmentin is advisable. Also, aspartame is present in augmentin suspensions, which is a  source of phenylalanine and thus should given sensibly to patients suffering from phenylketonuria.

Interaction with other medicinal products: Use of augmentin along with probenecid and allopurinol is not recommended because of the presence of amoxicillin in augmentin. Renal tubular secretion of amoxicillin is reduced by probenecid resulting in a prolonged amoxicillin level in blood. Allopurinol increases the chance of allergic reactions. Augmentin tablets also affects the gut flora and decreases the effectiveness of oral contraceptives. Increase in prothrombin time is also noted in rare cases.

Undesirable effects: After analyzing various data arranged from different clinical trials the following undesirable effects of augmentin can be recognized.

Common problems include infestations of Mucocutaneous candidiasis, Diarrhoea, Nausea and vomiting. Use of augmentin at the start of the meal can be helpful. Rare side effects include reversible leucopenia, thrombocytopenia, prolongation of bleeding time and prothrombin time, anaphylaxis, hypersensitivity vasculitis, angioneurotic oedema, dizziness, headache, convulsions, Indigestion, antibiotic-associated colitis,  superficial tooth discolouration (can be avoided by good oral hygiene), hepatitis and cholestatic jaundice (very rare), skin rash, urticaria, pruritus, Stevens-Johnson syndrome (very rare), interstitial nephritis, crystalluria (very rare) and several other complications which are all very rare and occur when prolonged use has to carried out due to other medical complications.

Interesting facts:

  • Augmentin tablets can only be used for bacterial infections and is ineffective against viral infections like flu and common cold.
  •  Over use or misuse of augmentin like any other antibiotics will cause in decrease of its effectiveness. In case of overdose removal of augmentin from the circulation can be achieved by haemodialysis.
  • Augmentin should be stored below 25°C in cool, dark and dry place.

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