Actonel 35mg tablets

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Actonel generic (risedronate) is used to prevent osteoporosis in women in postmenopausal period or in patients with corticosteroid-related osteoporosis. The medication works by decreasing bone loss in the organism. 

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Actonel 35mg tablets

Actonel 35mg tablets Learn more about osteoporosis treatment with actonel generic 35mg. Generic medicine made by Cipla
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Generic Actonel contains the active ingredient – risedronate that belongs to a group of medications called bisphosphonates. Risedronate or risedronic acid binds to the hydroxyapatite crystals of bone tissue. Therapeutic effect of risedronic acid on bone metabolism is associated with inhibition of osteoclasts and resorption reduction of bone tissue. At the same time the activity of osteoblasts remains and bone mineralization process continues. Inhibition of bone resorption caused by risedronic acid is reversible and dose-dependent. After termination of treatment the activity of osteoclasts is restored.
Therapeutic effect is usually observed in 3 months. Risedronic acid reduces the risk of vertebral compression fractures and proximal femur in osteoporosis in postmenopausal women and in patients with long-term treatment with glucocorticosteroid. It is also beneficial in women with postmenopausal osteoporosis.


Clinical use: Actonel (Risdedronate) is indicated in the following conditions:
• Prevention and treatment of osteoporosis in postmenopausal women
• Treatment of osteoporosis induced by corticosteroid therapy
• Paget's diseases in men and women

Mode of administration:
Actonel generic 35mg tablets are taken orally . The recommended adult dose is 1 tablet of Actonel 35 mg 1 time per week (always taken in the same day of the week ) .

Actonel generic 35 mg tablet should be taken in the morning for at least 30 minutes before the first food or drink (except for drinking water.

If you accidentally missed doses, Actonel 35 mg tablet should be taken as soon as possible during the day when you noticed that dose was missed. After that you should continue taking the medicine 1 time per week on the same day in which the medicament is taken earlier. Do not take 2 tablets at the same time.
Take 35mg tablets as a whole with a full glass of water.

Elderly patients

Dose adjustment Actonel 35 mg tablets is not required , since bioavailability, distribution and excretion of the remedy in elderly patients (over 60 years) are comparable to those in younger patients . Similar results were obtained in patients in very late postmenopausal women (75 years and older).

Patients with renal failure

In patients with renal insufficiency mild to moderate (creatinine clearance ≥ 30 ml / min) the correction of dose regimen is not required. There is limited clinical data on the use of the medicament Actonel ® in patients with severe renal insufficiency (creatinine clearance <30 mL / min) , so it is not possible to give any recommendations regarding dose in this patients. Safety and efficacy of Actonel ® tablets 35 mg in children and adolescents have not been established .

Actonel generic 35mg overdose:

A number of patients after a large overdose can expect a significant decrease in serum calcium. Some of these patients may also experience the signs and symptoms of hypocalcemia.

Treatment of overdose :
There is no any specific information about acute overdose of actonel 35mg. In case of overdose it is recommended to make gastric lavage. To bind risedronic acid and reduce its absorption it is recommended to give milk or antacids containing magnesium, calcium or aluminum.

Actonel generic 35mg tablets are contraindicated for use in patients with:

  • Renal failure (decreased creatinine clearance less than 30ml/min),
  • Hypocalcemia (low calcium blood levels)
  • Patients under 18 years of age
  • An inability to sit upright or stand for 30 minutes
  • Difficulties with swallowing (esophagus problems)
  • Pregnancy
  • Breastfeeding

Make sure to let your doctor know if you planning to have dental procedure.

Special cautions
Do not take Actonel 35mg with foods, beverages and medicaments containing multivalent cations (such as calcium, magnesium, iron and aluminum), as this may affect the absorption of risedronate sodium.

Some bisphosphonates are associated with esophagitis and esophageal ulcers . Therefore, patients must carefully follow the instructions on the dose regimen and method of.

Actonel generic should be used with caution in patients who are unable to be upright at least for 30 minutes after medicine administration.

In cancer patients treated with bisphosphonates, osteonecrosis of the jaw was observed , usually with tooth extraction and local infection (including osteomyelitis) . Many of these patients received chemotherapy and glucocorticosteroid medicaments.

Actonel side effect:

The most common Actonel side effects include:

  • Back pain
  • Joint pain
  • Stomach pain
  • Urinary tract infection
  • Diarrhea
  • Hypertension
  • Nausea
  • Dizziness
  • Neck pain
  • Prostate enlargement
  • Leg cramps

Less common Risedronate side effects include: hernia, tumors, chest pain, gas, anemia, depression, pneumonia, cataracts

Druh Interactions: Actonel generic (risedronate) should not be used with the following groups of medicines or preparations:

  • Iron supplement
  • Magnesium supplements
  • Calcium products
  • NSAID's
  • Aspirin
  • Other osteoporosis treatment medications (teriparatide)

Attention: The remedy should not be administered without a consultation with a health care provider. Keep out of reach of children.

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